Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

Iron-regulatory proteins (IRPs) 1 and 2 posttranscriptionally regulate expression of transferrin receptor (TfR), ferritin, and other iron metabolism proteins. Mice with targeted deletion of IRP2 overexpress ferritin and express abnormally low TfR levels in multiple tissues. Despite this misregulatio...

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Detalhes bibliográficos
Main Authors: Cooperman, Sharon S., Meyron-Holtz, Esther G., Olivierre-Wilson, Hayden, Ghosh, Manik C., McConnell, Joseph P., Rouault, Tracey A.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2005 by The American Society of Hematology 2005
Assuntos:
Red Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895161/
https://ncbi.nlm.nih.gov/pubmed/15831703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-12-4703
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