Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

Iron-regulatory proteins (IRPs) 1 and 2 posttranscriptionally regulate expression of transferrin receptor (TfR), ferritin, and other iron metabolism proteins. Mice with targeted deletion of IRP2 overexpress ferritin and express abnormally low TfR levels in multiple tissues. Despite this misregulatio...

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Autors principals: Cooperman, Sharon S., Meyron-Holtz, Esther G., Olivierre-Wilson, Hayden, Ghosh, Manik C., McConnell, Joseph P., Rouault, Tracey A.
Format: Artigo
Idioma:Inglês
Publicat: © 2005 by The American Society of Hematology 2005
Matèries:
Red Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895161/
https://ncbi.nlm.nih.gov/pubmed/15831703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-12-4703
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