The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease

COPD is characterized by persistent airflow limitation, neutrophilia and oxidative stress from endogenous and exogenous insults. Current COPD therapy involving anticholinergics, β(2)-adrenoceptor agonists and/or corticosteroids, do not specifically target oxidative stress, nor do they reduce chronic...

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Udgivet i:Sci Rep
Main Authors: Han, Bing, Poppinga, Wilfred J., Zuo, Haoxiao, Zuidhof, Annet B., Bos, I. Sophie T., Smit, Marieke, Vogelaar, Pieter, Krenning, Guido, Henning, Robert H., Maarsingh, Harm, Halayko, Andrew J., van Vliet, Bernard, Stienstra, Stef, Graaf, Adrianus Cornelis van der, Meurs, Herman, Schmidt, Martina
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882609/
https://ncbi.nlm.nih.gov/pubmed/27229886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26928
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