Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness

1. A deficiency of constitutive nitric oxide synthase (cNOS)-derived nitric oxide (NO), due to reduced availability of L-arginine, importantly contributes to allergen-induced airway hyperresponsiveness (AHR) after the early asthmatic reaction (EAR). Since cNOS and arginase use L-arginine as a common...

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Detalhes bibliográficos
Main Authors: Meurs, Herman, McKay, Sue, Maarsingh, Harm, Hamer, Marco A M, Macic, Lejla, Molendijk, Niek, Zaagsma, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573363/
https://ncbi.nlm.nih.gov/pubmed/12023942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704725
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