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Arginase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxation

BACKGROUND: Recent evidence suggests that endogenous arginase activity potentiates airway responsiveness to methacholine by attenuation of agonist-induced nitric oxide (NO) production, presumably by competition with epithelial constitutive NO synthase for the common substrate, L-arginine. Using guin...

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Detalhes bibliográficos
Main Authors: Maarsingh, Harm, Tio, Marieke A, Zaagsma, Johan, Meurs, Herman
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC555585/
https://ncbi.nlm.nih.gov/pubmed/15748286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-6-23
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