Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma

BACKGROUND: Using guinea pig tracheal preparations, we have recently shown that endogenous arginase activity attenuates inhibitory nonadrenergic noncholinergic (iNANC) nerve-mediated airway smooth muscle relaxation by reducing nitric oxide (NO) production – due to competition with neuronal NO-syntha...

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Detalhes bibliográficos
Main Authors: Maarsingh, Harm, Leusink, John, Bos, I Sophie T, Zaagsma, Johan, Meurs, Herman
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1363345/
https://ncbi.nlm.nih.gov/pubmed/16409620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-7-6
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