Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction

BACKGROUND: In guinea pigs, we have previously demonstrated that the contribution of Rho-kinase to airway responsiveness in vivo and ex vivo is enhanced after active sensitization with ovalbumin (OA). Using conscious, unrestrained OA-sensitized guina pigs, we now investigated the role of Rho-kinase...

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Bibliographic Details
Main Authors: Schaafsma, Dedmer, Bos, I Sophie T, Zuidhof, Annet B, Zaagsma, Johan, Meurs, Herman
Format: Artigo
Language:Inglês
Published: BioMed Central 2006
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1586199/
https://ncbi.nlm.nih.gov/pubmed/17002806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-7-121
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