Tumor Suppressor Folliculin Regulates mTORC1 through Primary Cilia

Folliculin (FLCN) is the tumor suppressor associated with Birt-Hogg-Dubé (BHD) syndrome that predisposes patients to incident of hamartomas and cysts in multiple organs. Its inactivation causes deregulation in the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway. However, the under...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Zhong, Mingming, Zhao, Xuwen, Li, Jinmei, Yuan, Wenjie, Yan, Gonghong, Tong, Mingming, Guo, Shuguang, Zhu, Yichao, Jiang, Yong, Liu, Yongjian, Jiang, Yu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882437/
https://ncbi.nlm.nih.gov/pubmed/27072130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.719997
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