Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency

To reveal how cells exit human pluripotency, we designed a CRISPR-Cas9 screen exploiting the metabolic and epigenetic differences between naïve and primed pluripotent cells. We identify the tumor suppressor, Folliculin(FLCN) as a critical gene required for the exit from human pluripotency. Here we s...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Mathieu, J., Detraux, D., Kuppers, D., Wang, Y., Cavanaugh, C., Sidhu, S., Levy, S., Robitaille, A. M., Ferreccio, A., Bottorff, T., McAlister, A., Somasundaram, L., Artoni, F., Battle, S., Hawkins, R. D., Moon, R. T., Ware, C. B., Paddison, P. J., Ruohola-Baker, H.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367455/
https://ncbi.nlm.nih.gov/pubmed/30733432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08020-0
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