Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation

Cardiac hypertrophy, an adaptive process that responds to increased wall stress, is characterized by the enlargement of cardiomyocytes and structural remodeling. It is stimulated by various growth signals, of which the mTORC1 pathway is a well-recognized source. Here, we show that loss of Flcn, a no...

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Detalhes bibliográficos
Main Authors: Hasumi, Yukiko, Baba, Masaya, Hasumi, Hisashi, Huang, Ying, Lang, Martin, Reindorf, Rachel, Oh, Hyoung-bin, Sciarretta, Sebastiano, Nagashima, Kunio, Haines, Diana C., Schneider, Michael D., Adelstein, Robert S., Schmidt, Laura S., Sadoshima, Junichi, Marston Linehan, W.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189904/
https://ncbi.nlm.nih.gov/pubmed/24908670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu286
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