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Crystal structure of the Rous sarcoma virus intasome
Integration of the reverse-transcribed viral DNA into the host genome is an essential step in the lifecycle of retroviruses. Retrovirus integrase (IN) catalyzes insertions of both ends of the linear viral DNA into a host chromosome (1). IN from HIV-1 and closely related retroviruses share the three-...
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| Veröffentlicht in: | Nature |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4881392/ https://ncbi.nlm.nih.gov/pubmed/26887497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16950 |
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