Rous Sarcoma Virus Synaptic Complex Capable of Concerted Integration Is Kinetically Trapped by Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors

We determined conditions to produce milligram quantities of the soluble Rous sarcoma virus (RSV) synaptic complex that is kinetically trapped by HIV strand transfer inhibitors (STIs). Concerted integration catalyzed by RSV integrase (IN) is effectively inhibited by HIV STIs. Optimized assembly of th...

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Detalhes bibliográficos
Main Authors: Pandey, Krishan K., Bera, Sibes, Korolev, Sergey, Campbell, Mary, Yin, Zhiqi, Aihara, Hideki, Grandgenett, Duane P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094075/
https://ncbi.nlm.nih.gov/pubmed/24872410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.573311
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