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A Possible Role for the Asymmetric C-Terminal Domain Dimer of Rous Sarcoma Virus Integrase in Viral DNA Binding

Integration of the retrovirus linear DNA genome into the host chromosome is an essential step in the viral replication cycle, and is catalyzed by the viral integrase (IN). Evidence suggests that IN functions as a dimer that cleaves a dinucleotide from the 3′ DNA blunt ends while a dimer of dimers (t...

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Detalhes bibliográficos
Main Authors: Shi, Ke, Pandey, Krishan K., Bera, Sibes, Vora, Ajaykumar C., Grandgenett, Duane P., Aihara, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579926/
https://ncbi.nlm.nih.gov/pubmed/23451105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056892
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