TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin

Regulating the transcription, translation and secretion of cytokines is crucial for controlling the appropriate balance of inflammation. Here we report that the sorting receptor sortilin plays a key role in cytokine production. We observed interactions of sortilin with multiple cytokines including I...

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Publicado no:Sci Rep
Main Authors: Yabe-Wada, Toshiki, Matsuba, Shintaro, Takeda, Kazuya, Sato, Tetsuya, Suyama, Mikita, Ohkawa, Yasuyuki, Takai, Toshiyuki, Shi, Haifeng, Philpott, Caroline C., Nakamura, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879639/
https://ncbi.nlm.nih.gov/pubmed/27220277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26566
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