TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin

Regulating the transcription, translation and secretion of cytokines is crucial for controlling the appropriate balance of inflammation. Here we report that the sorting receptor sortilin plays a key role in cytokine production. We observed interactions of sortilin with multiple cytokines including I...

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Publicado en:Sci Rep
Autores principales: Yabe-Wada, Toshiki, Matsuba, Shintaro, Takeda, Kazuya, Sato, Tetsuya, Suyama, Mikita, Ohkawa, Yasuyuki, Takai, Toshiyuki, Shi, Haifeng, Philpott, Caroline C., Nakamura, Akira
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879639/
https://ncbi.nlm.nih.gov/pubmed/27220277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26566
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