Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

Mutations in the progranulin (PGRN) gene have been linked to two distinct neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests a critical role of PGRN in lysosomes. However, how PGRN is trafficked to lysosomes i...

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Detaylı Bibliyografya
Yayımlandı:J Cell Biol
Asıl Yazarlar: Zhou, Xiaolai, Sun, Lirong, Bastos de Oliveira, Francisco, Qi, Xiaoyang, Brown, William J., Smolka, Marcus B., Sun, Ying, Hu, Fenghua
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2015
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576858/
https://ncbi.nlm.nih.gov/pubmed/26370502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201502029
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