Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

Mutations in the progranulin (PGRN) gene have been linked to two distinct neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests a critical role of PGRN in lysosomes. However, how PGRN is trafficked to lysosomes i...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Cell Biol
Huvudupphovsmän: Zhou, Xiaolai, Sun, Lirong, Bastos de Oliveira, Francisco, Qi, Xiaoyang, Brown, William J., Smolka, Marcus B., Sun, Ying, Hu, Fenghua
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2015
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576858/
https://ncbi.nlm.nih.gov/pubmed/26370502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201502029
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk