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Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
Mutations in the progranulin (PGRN) gene have been linked to two distinct neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests a critical role of PGRN in lysosomes. However, how PGRN is trafficked to lysosomes i...
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| Yayımlandı: | J Cell Biol |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Rockefeller University Press
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4576858/ https://ncbi.nlm.nih.gov/pubmed/26370502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201502029 |
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