Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

Mutations in the progranulin (PGRN) gene have been linked to two distinct neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests a critical role of PGRN in lysosomes. However, how PGRN is trafficked to lysosomes i...

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Publicado en:J Cell Biol
Autores principales: Zhou, Xiaolai, Sun, Lirong, Bastos de Oliveira, Francisco, Qi, Xiaoyang, Brown, William J., Smolka, Marcus B., Sun, Ying, Hu, Fenghua
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2015
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576858/
https://ncbi.nlm.nih.gov/pubmed/26370502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201502029
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