Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

Haploinsufficiency of progranulin (PGRN) due to mutations in the granulin (GRN) gene causes frontotemporal lobar degeneration (FTLD), and complete loss of PGRN leads to a lysosomal storage disorder, neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests that PGRN is essential for prope...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhou, Xiaolai, Sun, Lirong, Bracko, Oliver, Choi, Ji Whae, Jia, Yan, Nana, Alissa L., Brady, Owen Adam, Hernandez, Jean C. Cruz, Nishimura, Nozomi, Seeley, William W., Hu, Fenghua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477518/
https://ncbi.nlm.nih.gov/pubmed/28541286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15277
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados