The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function

Haploinsufficiency of Progranulin (PGRN), a gene encoding a secreted glycoprotein, is a major cause of frontotemporal lobar degeneration with ubiquitin (FTLD-U) positive inclusions. Single nucleotide polymorphisms in the TMEM106B gene were recently discovered as a risk factor for FTLD-U, especially...

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Bibliografiska uppgifter
Huvudupphovsmän: Brady, Owen A., Zheng, Yanqiu, Murphy, Kira, Huang, Marshall, Hu, Fenghua
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2013
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554197/
https://ncbi.nlm.nih.gov/pubmed/23136129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds475
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