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The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function
Haploinsufficiency of Progranulin (PGRN), a gene encoding a secreted glycoprotein, is a major cause of frontotemporal lobar degeneration with ubiquitin (FTLD-U) positive inclusions. Single nucleotide polymorphisms in the TMEM106B gene were recently discovered as a risk factor for FTLD-U, especially...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554197/ https://ncbi.nlm.nih.gov/pubmed/23136129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds475 |
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