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The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C
The frontotemporal lobar degeneration (FTLD) protein progranulin (PGRN) is essential for proper lysosomal function. PGRN localizes in the lysosomal compartment within the cell. Prosaposin (PSAP), the precursor of lysosomal saposin activators (saposin A, B, C, D), physically interacts with PGRN. Prev...
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| Publicado no: | J Neurochem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5630500/ https://ncbi.nlm.nih.gov/pubmed/28640985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14110 |
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