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The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C
The frontotemporal lobar degeneration (FTLD) protein progranulin (PGRN) is essential for proper lysosomal function. PGRN localizes in the lysosomal compartment within the cell. Prosaposin (PSAP), the precursor of lysosomal saposin activators (saposin A, B, C, D), physically interacts with PGRN. Prev...
Shranjeno v:
izdano v: | J Neurochem |
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Main Authors: | , , , |
Format: | Artigo |
Jezik: | Inglês |
Izdano: |
2017
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5630500/ https://ncbi.nlm.nih.gov/pubmed/28640985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14110 |
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