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The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C

The frontotemporal lobar degeneration (FTLD) protein progranulin (PGRN) is essential for proper lysosomal function. PGRN localizes in the lysosomal compartment within the cell. Prosaposin (PSAP), the precursor of lysosomal saposin activators (saposin A, B, C, D), physically interacts with PGRN. Prev...

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Bibliografske podrobnosti
izdano v:J Neurochem
Main Authors: Zhou, Xiaolai, Sullivan, Peter M., Sun, Lirong, Hu, Fenghua
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630500/
https://ncbi.nlm.nih.gov/pubmed/28640985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14110
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