C-Terminus of Progranulin Interacts with the Beta-Propeller Region of Sortilin to Regulate Progranulin Trafficking

Progranulin haplo-insufficiency is a main cause of frontotemporal lobar degeneration (FTLD) with TDP-43 aggregates. Previous studies have shown that sortilin regulates progranulin trafficking and is a main determinant of progranulin level in the brain. In this study, we mapped the binding site betwe...

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Detaylı Bibliyografya
Asıl Yazarlar: Zheng, Yanqiu, Brady, Owen A., Meng, Peter S., Mao, Yuxin, Hu, Fenghua
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115958/
https://ncbi.nlm.nih.gov/pubmed/21698296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021023
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