Sortilin-Mediated Endocytosis Determines Levels of the Fronto-Temporal Dementia Protein, Progranulin

The most common inherited form of Fronto-Temporal Lobar Degeneration (FTLD) known stems from Progranulin (GRN) mutation, and exhibits TDP-43 plus ubiquitin aggregates. Despite the causative role of GRN haploinsufficiency in FTLD-TDP, the neurobiology of this secreted glycoprotein is unclear. Here, w...

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Main Authors: Hu, Fenghua, Padukkavidana, Thihan, Vægter, Christian B., Brady, Owen A., Zheng, Yanqiu, Mackenzie, Ian R., Feldman, Howard H., Nykjaer, Anders, Strittmatter, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990962/
https://ncbi.nlm.nih.gov/pubmed/21092856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.09.034
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