TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin

Regulating the transcription, translation and secretion of cytokines is crucial for controlling the appropriate balance of inflammation. Here we report that the sorting receptor sortilin plays a key role in cytokine production. We observed interactions of sortilin with multiple cytokines including I...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Yabe-Wada, Toshiki, Matsuba, Shintaro, Takeda, Kazuya, Sato, Tetsuya, Suyama, Mikita, Ohkawa, Yasuyuki, Takai, Toshiyuki, Shi, Haifeng, Philpott, Caroline C., Nakamura, Akira
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879639/
https://ncbi.nlm.nih.gov/pubmed/27220277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26566
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