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Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease
Recent studies have identified impairments in neural induction and in striatal and cortical neurogenesis in Huntington’s disease (HD) knock-in mouse models and associated embryonic stem cell lines. However, the potential role of these developmental alterations for HD pathogenesis and progression is...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4878495/ https://ncbi.nlm.nih.gov/pubmed/27140644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603871113 |
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