Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington’s disease

The mutation in huntingtin (mHtt) leads to a spectrum of impairments in the developing forebrain of Huntington’s disease (HD) mouse models. Whether these developmental alterations are due to loss- or gain-of-function mechanisms and contribute to HD pathogenesis is unknown. We examined the role of se...

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Bibliographic Details
Published in:Neurobiol Dis
Main Authors: Arteaga-Bracho, Eduardo E., Gulinello, Maria, Winchester, Michael L., Pichamoorthy, Nandini, Petronglo, Jenna R., Zambrano, Alicia D., Inocencio, Julio, De Jesus, Chirstopher D., Louie, Joseph O., Gokhan, Solen, Mehler, Mark F., Molero, Aldrin E.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5102778/
https://ncbi.nlm.nih.gov/pubmed/27623015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.09.006
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