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Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease
Recent studies have identified impairments in neural induction and in striatal and cortical neurogenesis in Huntington’s disease (HD) knock-in mouse models and associated embryonic stem cell lines. However, the potential role of these developmental alterations for HD pathogenesis and progression is...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4878495/ https://ncbi.nlm.nih.gov/pubmed/27140644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603871113 |
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