Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease

Recent studies have identified impairments in neural induction and in striatal and cortical neurogenesis in Huntington’s disease (HD) knock-in mouse models and associated embryonic stem cell lines. However, the potential role of these developmental alterations for HD pathogenesis and progression is...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Molero, Aldrin E., Arteaga-Bracho, Eduardo E., Chen, Christopher H., Gulinello, Maria, Winchester, Michael L., Pichamoorthy, Nandini, Gokhan, Solen, Khodakhah, Kamran, Mehler, Mark F.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878495/
https://ncbi.nlm.nih.gov/pubmed/27140644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603871113
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