The ssDNA Mutator APOBEC3A is Regulated by Cooperative Dimerization

Deaminase activity mediated by the human APOBEC3 family of proteins contributes to genomic instability and cancer. APOBEC3A is by far the most active in this family and can cause rapid cell death when overexpressed, but in general how the activity of APOBEC3s is regulated on a molecular level is unc...

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Udgivet i:Structure
Main Authors: Bohn, Markus-Frederik, Shandilya, Shivender M.D., Silvas, Tania V., Nalivaika, Ellen A., Kouno, Takahide, Kelch, Brian A., Ryder, Sean P., Kurt-Yilmaz, Nese, Somasundaran, Mohan, Schiffer, Celia A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874493/
https://ncbi.nlm.nih.gov/pubmed/25914058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.03.016
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