Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

The APOBEC3 (A3) family of human cytidine deaminases is renowned for providing a first line of defense against many exogenous and endogenous retroviruses. However, the ability of these proteins to deaminate deoxycytidines in ssDNA makes A3s a double-edged sword. When overexpressed, A3s can mutate en...

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Pubblicato in:Sci Rep
Autori principali: Silvas, Tania V., Hou, Shurong, Myint, Wazo, Nalivaika, Ellen, Somasundaran, Mohan, Kelch, Brian A., Matsuo, Hiroshi, Kurt Yilmaz, Nese, Schiffer, Celia A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951847/
https://ncbi.nlm.nih.gov/pubmed/29760455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25881-z
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