Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA

The potent antiretroviral protein APOBEC3G (A3G) specifically targets and deaminates deoxycytidine nucleotides, generating deoxyuridine, in single stranded DNA (ssDNA) intermediates produced during HIV replication. A non-catalytic domain in A3G binds strongly to RNA, an interaction crucial for recru...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Solomon, William C, Myint, Wazo, Hou, Shurong, Kanai, Tapan, Tripathi, Rashmi, Kurt Yilmaz, Nese, Schiffer, Celia A, Matsuo, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698744/
https://ncbi.nlm.nih.gov/pubmed/31424549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz550
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