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Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA
The potent antiretroviral protein APOBEC3G (A3G) specifically targets and deaminates deoxycytidine nucleotides, generating deoxyuridine, in single stranded DNA (ssDNA) intermediates produced during HIV replication. A non-catalytic domain in A3G binds strongly to RNA, an interaction crucial for recru...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6698744/ https://ncbi.nlm.nih.gov/pubmed/31424549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz550 |
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