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Crystal structure of a soluble APOBEC3G variant suggests ssDNA to bind in a channel that extends between the two domains.
APOBEC3G (A3G) is a single-stranded DNA (ssDNA) cytosine deaminase that can restrict HIV-1 infection by mutating the viral genome. A3G consists of a non-catalytic N-terminal domain (NTD) and a catalytic C-terminal domain (CTD) connected by a short linker. While the CTD catalyzes cytosine deamination...
Shranjeno v:
| izdano v: | J Mol Biol |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7771068/ https://ncbi.nlm.nih.gov/pubmed/33098858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.10.020 |
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