Crystal structure of a soluble APOBEC3G variant suggests ssDNA to bind in a channel that extends between the two domains.

APOBEC3G (A3G) is a single-stranded DNA (ssDNA) cytosine deaminase that can restrict HIV-1 infection by mutating the viral genome. A3G consists of a non-catalytic N-terminal domain (NTD) and a catalytic C-terminal domain (CTD) connected by a short linker. While the CTD catalyzes cytosine deamination...

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Bibliografske podrobnosti
izdano v:J Mol Biol
Main Authors: Maiti, Atanu, Myint, Wazo, Delviks-Frankenberry, Krista A., Hou, Shurong, Kanai, Tapan, Balachandran, Vanivilasini, Rodriguez, Christina Sierra, Tripathi, Rashmi, Yilmaz, Nese Kurt, Pathak, Vinay K., Schiffer, Celia A., Matsuo, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7771068/
https://ncbi.nlm.nih.gov/pubmed/33098858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.10.020
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