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Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s

The human cytidine deaminase family of APOBEC3s (A3s) plays critical roles in both innate immunity and the development of cancers. A3s comprise seven functionally overlapping but distinct members that can be exploited as nucleotide base editors for treating genetic diseases. Although overall structu...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Hou, Shurong, Lee, Jeong Min, Myint, Wazo, Matsuo, Hiroshi, Kurt Yilmaz, Nese, Schiffer, Celia A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313598/
https://ncbi.nlm.nih.gov/pubmed/34171358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100909
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