Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s

The human cytidine deaminase family of APOBEC3s (A3s) plays critical roles in both innate immunity and the development of cancers. A3s comprise seven functionally overlapping but distinct members that can be exploited as nucleotide base editors for treating genetic diseases. Although overall structu...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Hou, Shurong, Lee, Jeong Min, Myint, Wazo, Matsuo, Hiroshi, Kurt Yilmaz, Nese, Schiffer, Celia A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2021
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ASBMB Award Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313598/
https://ncbi.nlm.nih.gov/pubmed/34171358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100909
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