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Structural analysis of the active site and DNA binding of human cytidine deaminase APOBEC3B
APOBEC3s proteins (A3s), a family of human cytidine deaminases, protect the host from endogenous retro-elements and exogenous viral infections by introducing hypermutations. However, overexpressed A3s can modify genomic DNA to promote tumorigenesis, especially A3B. Despite overall similarity, A3 pro...
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| 出版年: | J Chem Theory Comput |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6698902/ https://ncbi.nlm.nih.gov/pubmed/30457868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jctc.8b00545 |
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