Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

Nucleic acid editing enzymes are essential components of the immune system that lethally mutate viral pathogens and somatically mutate immunoglobulins, and contribute to the diversification and lethality of cancers. Among these enzymes are the seven human APOBEC3 deoxycytidine deaminases, each with...

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Pubblicato in:Nat Commun
Autori principali: Kouno, Takahide, Silvas, Tania V., Hilbert, Brendan J., Shandilya, Shivender M. D., Bohn, Markus F., Kelch, Brian A., Royer, William E., Somasundaran, Mohan, Kurt Yilmaz, Nese, Matsuo, Hiroshi, Schiffer, Celia A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414352/
https://ncbi.nlm.nih.gov/pubmed/28452355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15024
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