Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

Nucleic acid editing enzymes are essential components of the immune system that lethally mutate viral pathogens and somatically mutate immunoglobulins, and contribute to the diversification and lethality of cancers. Among these enzymes are the seven human APOBEC3 deoxycytidine deaminases, each with...

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Publicat a:Nat Commun
Autors principals: Kouno, Takahide, Silvas, Tania V., Hilbert, Brendan J., Shandilya, Shivender M. D., Bohn, Markus F., Kelch, Brian A., Royer, William E., Somasundaran, Mohan, Kurt Yilmaz, Nese, Matsuo, Hiroshi, Schiffer, Celia A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414352/
https://ncbi.nlm.nih.gov/pubmed/28452355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15024
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