Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design

Por Hilbert, Brendan J., Grossman, Steven R., Schiffer, Celia A., Royer, William E.
Publicado em 2014

The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain

Por Hilbert, Brendan J., Hayes, Janelle A., Stone, Nicholas P., Xu, Rui-Gang, Kelch, Brian A.
Publicado no Nucleic Acids Res (2017)

Structure and mechanism of the ATPase that powers viral genome packaging

Por Hilbert, Brendan J., Hayes, Janelle A., Stone, Nicholas P., Duffy, Caroline M., Sankaran, Banumathi, Kelch, Brian A.
Publicado no Proc Natl Acad Sci U S A (2015)

Structure-guided design of a high affinity inhibitor to human CtBP

Por Hilbert, Brendan J., Morris, Benjamin L., Ellis, Keith C., Paulsen, Janet L., Schiffer, Celia A., Grossman, Steven R., Royer, William E.
Publicado no ACS Chem Biol (2015)

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

Por Kouno, Takahide, Silvas, Tania V., Hilbert, Brendan J., Shandilya, Shivender M. D., Bohn, Markus F., Kelch, Brian A., Royer, William E., Somasundaran, Mohan, Kurt Yilmaz, Nese, Matsuo, Hiroshi, Schiffer, Celia A.
Publicado no Nat Commun (2017)

Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-Terminal Binding Protein (CtBP)

Por Korwar, Sudha, Morris, Benjamin L., Parikh, Hardik I., Coover, Robert A., Doughty, Tyler W., Love, Ian M., Hilbert, Brendan J., Royer, William E., Kellogg, Glen E., Grossman, Steven R., Ellis, Keith C.
Publicado no Bioorg Med Chem (2016)