Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-Terminal Binding Protein (CtBP)

C-terminal Binding Protein (CtBP) is a transcriptional co-regulator that downregulates the expression of many tumor-suppressor genes. Utilizing a crystal structure of CtBP with its substrate 4-methylthio-2-oxobutyric acid (MTOB) and NAD(+) as a guide, we have designed, synthesized, and tested a seri...

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Publicado no:Bioorg Med Chem
Main Authors: Korwar, Sudha, Morris, Benjamin L., Parikh, Hardik I., Coover, Robert A., Doughty, Tyler W., Love, Ian M., Hilbert, Brendan J., Royer, William E., Kellogg, Glen E., Grossman, Steven R., Ellis, Keith C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993153/
https://ncbi.nlm.nih.gov/pubmed/27156192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.04.037
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