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Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design

The oncogenic corepressors C-terminal Binding Protein (CtBP) 1 and 2 harbor regulatory D-isomer specific 2-hydroxyacid dehydrogenase (D2-HDH) domains. 4-Methylthio 2-oxobutyric acid (MTOB) exhibits substrate inhibition and can interfere with CtBP oncogenic activity in cell culture and mice. Crystal...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hilbert, Brendan J., Grossman, Steven R., Schiffer, Celia A., Royer, William E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072453/
https://ncbi.nlm.nih.gov/pubmed/24657618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.03.026
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