Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design

Lignende værker

• Structure-guided design of a high affinity inhibitor to human CtBP
  af: Hilbert, Brendan J., et al.
  Udgivet: (2015)
• Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-Terminal Binding Protein (CtBP)
  af: Korwar, Sudha, et al.
  Udgivet: (2016)
• Assembly of human C-terminal binding protein (CtBP) into tetramers
  af: Bellesis, Andrew G., et al.
  Udgivet: (2018)
• NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP)
  af: Nichols, Jeffry C., et al.
  Udgivet: (2021)
• Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities
  af: Dcona, M. Michael, et al.
  Udgivet: (2019)