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Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design
The oncogenic corepressors C-terminal Binding Protein (CtBP) 1 and 2 harbor regulatory D-isomer specific 2-hydroxyacid dehydrogenase (D2-HDH) domains. 4-Methylthio 2-oxobutyric acid (MTOB) exhibits substrate inhibition and can interfere with CtBP oncogenic activity in cell culture and mice. Crystal...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4072453/ https://ncbi.nlm.nih.gov/pubmed/24657618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.03.026 |
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