Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-Terminal Binding Protein (CtBP)

C-terminal Binding Protein (CtBP) is a transcriptional co-regulator that downregulates the expression of many tumor-suppressor genes. Utilizing a crystal structure of CtBP with its substrate 4-methylthio-2-oxobutyric acid (MTOB) and NAD(+) as a guide, we have designed, synthesized, and tested a seri...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Bioorg Med Chem
Main Authors: Korwar, Sudha, Morris, Benjamin L., Parikh, Hardik I., Coover, Robert A., Doughty, Tyler W., Love, Ian M., Hilbert, Brendan J., Royer, William E., Kellogg, Glen E., Grossman, Steven R., Ellis, Keith C.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993153/
https://ncbi.nlm.nih.gov/pubmed/27156192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.04.037
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares