Class II HLA interactions modulate genetic risk for multiple sclerosis

Association studies have greatly refined the understanding of how variation within the human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the extent to which major effects are modulated by interactions is poorly characterized. We analyzed high-density SNP data on 17,...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Moutsianas, Loukas, Jostins, Luke, Beecham, Ashley H, Dilthey, Alexander T, Xifara, Dionysia K, Ban, Maria, Shah, Tejas S, Patsopoulos, Nikolaos A, Alfredsson, Lars, Anderson, Carl A, Attfield, Katherine E, Baranzini, Sergio E, Barrett, Jeffrey, Binder, Thomas M C, Booth, David, Buck, Dorothea, Celius, Elisabeth G, Cotsapas, Chris, D’Alfonso, Sandra, Dendrou, Calliope A, Donnelly, Peter, Dubois, Bénédicte, Fontaine, Bertrand, Fugger, Lars, Goris, An, Gourraud, Pierre-Antoine, Graetz, Christiane, Hemmer, Bernhard, Hillert, Jan, Kockum, Ingrid, Leslie, Stephen, Lill, Christina M, Martinelli-Boneschi, Filippo, Oksenberg, Jorge R, Olsson, Tomas, Oturai, Annette, Saarela, Janna, Søndergaard, Helle Bach, Spurkland, Anne, Taylor, Bruce, Winkelmann, Juliane, Zipp, Frauke, Haines, Jonathan L, Pericak-Vance, Margaret A, Spencer, Chris C A, Stewart, Graeme, Hafler, David A, Ivinson, Adrian J, Harbo, Hanne F, Hauser, Stephen L, De Jager, Philip L, Compston, Alastair, McCauley, Jacob L, Sawcer, Stephen, McVean, Gil
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874245/
https://ncbi.nlm.nih.gov/pubmed/26343388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3395
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