Class II HLA interactions modulate genetic risk for multiple sclerosis

Association studies have greatly refined the understanding of how variation within the human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the extent to which major effects are modulated by interactions is poorly characterized. We analyzed high-density SNP data on 17,...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Nat Genet
Κύριοι συγγραφείς: Moutsianas, Loukas, Jostins, Luke, Beecham, Ashley H, Dilthey, Alexander T, Xifara, Dionysia K, Ban, Maria, Shah, Tejas S, Patsopoulos, Nikolaos A, Alfredsson, Lars, Anderson, Carl A, Attfield, Katherine E, Baranzini, Sergio E, Barrett, Jeffrey, Binder, Thomas M C, Booth, David, Buck, Dorothea, Celius, Elisabeth G, Cotsapas, Chris, D’Alfonso, Sandra, Dendrou, Calliope A, Donnelly, Peter, Dubois, Bénédicte, Fontaine, Bertrand, Fugger, Lars, Goris, An, Gourraud, Pierre-Antoine, Graetz, Christiane, Hemmer, Bernhard, Hillert, Jan, Kockum, Ingrid, Leslie, Stephen, Lill, Christina M, Martinelli-Boneschi, Filippo, Oksenberg, Jorge R, Olsson, Tomas, Oturai, Annette, Saarela, Janna, Søndergaard, Helle Bach, Spurkland, Anne, Taylor, Bruce, Winkelmann, Juliane, Zipp, Frauke, Haines, Jonathan L, Pericak-Vance, Margaret A, Spencer, Chris C A, Stewart, Graeme, Hafler, David A, Ivinson, Adrian J, Harbo, Hanne F, Hauser, Stephen L, De Jager, Philip L, Compston, Alastair, McCauley, Jacob L, Sawcer, Stephen, McVean, Gil
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2015
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874245/
https://ncbi.nlm.nih.gov/pubmed/26343388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3395
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