TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

Although there has been much success in identifying genetic variants associated with common diseases using genome-wide association studies (GWAS)(1), it has been difficult to demonstrate which variants are causal and what role they play in disease. Moreover, the modest contribution these variants ma...

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Publicado no:Nature
Main Authors: Gregory, Adam P., Dendrou, Calliope A., Attfield, Kathrine E., Haghikia, Aiden, Xifara, Dionysia K., Butter, Falk, Poschmann, Gereon, Kaur, Gurman, Lambert, Lydia, Leach, Oliver A., Prömel, Simone, Punwani, Divya, Felce, James H., Davis, Simon J., Gold, Ralf, Nielsen, Finn C., Siegel, Richard M., Mann, Matthias, Bell, John I., McVean, Gil, Fugger, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268493/
https://ncbi.nlm.nih.gov/pubmed/22801493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11307
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