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Novel positive allosteric modulators of GABA(A) receptors with anesthetic activity

GABA(A) receptors are the main inhibitory neurotransmitter receptors in the brain and are targets for numerous clinically important drugs such as benzodiazepines, anxiolytics and anesthetics. We previously identified novel ligands of the classical benzodiazepine binding pocket in α(1)β(2)γ(2) GABA(A...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Maldifassi, Maria C., Baur, Roland, Pierce, David, Nourmahnad, Anahita, Forman, Stuart A., Sigel, Erwin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873749/
https://ncbi.nlm.nih.gov/pubmed/27198062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25943
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