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α subunits in GABA(A) receptors are dispensable for GABA and diazepam action
The major isoform of the GABA(A) receptor is α(1)β(2)γ(2). The binding sites for the agonist GABA are located at the β(2)+/α(1)− subunit interfaces and the modulatory site for benzodiazepines at α(1)+/γ(2)−. In the absence of α(1) subunits, a receptor was formed that was gated by GABA and modulated...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5686171/ https://ncbi.nlm.nih.gov/pubmed/29138471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15628-7 |
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