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α subunits in GABA(A) receptors are dispensable for GABA and diazepam action
The major isoform of the GABA(A) receptor is α(1)β(2)γ(2). The binding sites for the agonist GABA are located at the β(2)+/α(1)− subunit interfaces and the modulatory site for benzodiazepines at α(1)+/γ(2)−. In the absence of α(1) subunits, a receptor was formed that was gated by GABA and modulated...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5686171/ https://ncbi.nlm.nih.gov/pubmed/29138471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15628-7 |
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