Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism

Mycobacterium tuberculosis (Mtb) survives within macrophages by evading delivery to the lysosome and promoting the accumulation of lipid bodies, which serve as a bacterial source of nutrients. Here we show that by inducing miR-33 and its passenger strand miR-33*, Mtb inhibits integrated pathways inv...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Ouimet, Mireille, Koster, Stefan, Sakowski, Erik, Ramkhelawon, Bhama, van Solingen, Coen, Oldebeken, Scott, Karunakaran, Denuja, Celhay, Cynthia Portal, Sheedy, Frederick J., Ray, Tathagat Dutta, Cecchini, Katharine, Zamore, Philip D, Rayner, Katey J, Marcel, Yves L, Philips, Jennifer A, Moore, Kathryn J
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873392/
https://ncbi.nlm.nih.gov/pubmed/27089382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3434
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