Netrin-1 promotes adipose tissue macrophage accumulation and insulin resistance in obesity

During obesity, macrophage accumulation in adipose tissue propagates the chronic inflammation and insulin resistance associated with type 2 diabetes. The factors that regulate the accrual of macrophages in adipose are not well understood. Here we show that the neuroimmune guidance cue netrin-1 is hi...

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Main Authors: Ramkhelawon, Bhama, Hennessy, Elizabeth J, Ménager, Mickaël, Ray, Tathagat Dutta, Sheedy, Frederick J, Hutchison, Susan, Wanschel, Amarylis, Oldebeken, Scott, Geoffrion, Michele, Spiro, Westley, Miller, George, McPherson, Ruth, Rayner, Katey J, Moore, Kathryn J
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981930/
https://ncbi.nlm.nih.gov/pubmed/24584118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3467
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