Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis.

The success of Mycobacterium tuberculosis (Mtb) as a pathogen rests upon its ability to grow intracellularly in macrophages. Interferon-gamma (IFN-γ) is critical in host defense against Mtb and stimulates macrophage clearance of Mtb through an autophagy pathway. Here we show that the host protein ub...

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Main Authors: Erik T Sakowski, Stefan Koster, Cynthia Portal Celhay, Heidi S Park, Elina Shrestha, Stefanie E Hetzenecker, Katie Maurer, Ken Cadwell, Jennifer A Philips
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2015-07-01
Colecção:PLoS Pathogens
Acesso em linha:http://europepmc.org/articles/PMC4520715?pdf=render
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