MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

Cellular metabolism is increasingly recognized as a controller of immune cell fate and function. MicroRNA-33 (miR-33) regulates cellular lipid metabolism and represses genes involved in cholesterol efflux, HDL biogenesis, and fatty acid oxidation. Here, we determined that miR-33–mediated disruption...

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Pubblicato in:J Clin Invest
Autori principali: Ouimet, Mireille, Ediriweera, Hasini N., Gundra, U. Mahesh, Sheedy, Frederick J., Ramkhelawon, Bhama, Hutchison, Susan B., Rinehold, Kaitlyn, van Solingen, Coen, Fullerton, Morgan D., Cecchini, Katharine, Rayner, Katey J., Steinberg, Gregory R., Zamore, Phillip D., Fisher, Edward A., Loke, P’ng, Moore, Kathryn J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665799/
https://ncbi.nlm.nih.gov/pubmed/26517695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81676
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