MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

Cellular metabolism is increasingly recognized as a controller of immune cell fate and function. MicroRNA-33 (miR-33) regulates cellular lipid metabolism and represses genes involved in cholesterol efflux, HDL biogenesis, and fatty acid oxidation. Here, we determined that miR-33–mediated disruption...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ouimet, Mireille, Ediriweera, Hasini N., Gundra, U. Mahesh, Sheedy, Frederick J., Ramkhelawon, Bhama, Hutchison, Susan B., Rinehold, Kaitlyn, van Solingen, Coen, Fullerton, Morgan D., Cecchini, Katharine, Rayner, Katey J., Steinberg, Gregory R., Zamore, Phillip D., Fisher, Edward A., Loke, P’ng, Moore, Kathryn J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665799/
https://ncbi.nlm.nih.gov/pubmed/26517695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81676
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