MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

Cellular metabolism is increasingly recognized as a controller of immune cell fate and function. MicroRNA-33 (miR-33) regulates cellular lipid metabolism and represses genes involved in cholesterol efflux, HDL biogenesis, and fatty acid oxidation. Here, we determined that miR-33–mediated disruption...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Ouimet, Mireille, Ediriweera, Hasini N., Gundra, U. Mahesh, Sheedy, Frederick J., Ramkhelawon, Bhama, Hutchison, Susan B., Rinehold, Kaitlyn, van Solingen, Coen, Fullerton, Morgan D., Cecchini, Katharine, Rayner, Katey J., Steinberg, Gregory R., Zamore, Phillip D., Fisher, Edward A., Loke, P’ng, Moore, Kathryn J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665799/
https://ncbi.nlm.nih.gov/pubmed/26517695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81676
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