Identification of a small molecule that overcomes HdmX-mediated suppression of p53

Inactivation of the p53 tumor suppressor by mutation or overexpression of negative regulators occurs frequently in cancer. Since p53 plays a key role in regulating proliferation or apoptosis in response to DNA damaging chemotherapies, strategies aimed at reactivating p53 are increasingly being sough...

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Udgivet i:Mol Cancer Ther
Main Authors: Karan, Goutam, Wang, Huaiyu, Chakrabarti, Amit, Karan, Sukanya, Liu, Zhigang, Xia, Zhiqiang, Gundluru, Mahesh, Moreton, Stephen, Saunthararajah, Yogen, Jackson, Mark W, Agarwal, Mukesh K, Wald, David N
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873346/
https://ncbi.nlm.nih.gov/pubmed/26883273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0467
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