A carregar...
A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53
Cancer cells neutralize p53 by deletion, mutation, proteasomal degradation, or sequestration to achieve a pathologic survival advantage. Targeting the E3 ubiquitin ligase HDM2 can lead to a therapeutic surge in p53 levels. However, the efficacy of HDM2 inhibition can be compromised by overexpression...
Na minha lista:
| Main Authors: | , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050021/ https://ncbi.nlm.nih.gov/pubmed/21075307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.10.024 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|