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Quantitative analyses reveal the importance of regulated Hdmx degradation for P53 activation
P53 regulates numerous downstream targets to induce cell cycle arrest, senescence, apoptosis, and DNA repair in response to diverse stresses. Hdm2 and Hdmx are critical negative regulators of P53 because Hdm2 regulates P53 abundance, and both can antagonize P53 transactivation. Modest changes in Hdm...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1941475/ https://ncbi.nlm.nih.gov/pubmed/17640893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701497104 |
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